Jeanne Tripplehorn discusses directing “Five” Jeanne Tripplehorn says she didn’t hesitate when Jennifer Aniston phoned and asked her to be part of her “Five” movie that depicts five different stories of women dealing with breast cancer. “There are two breast cancer survivors on my mother’s side of the family, so this was a no-brainer. I was in. It’s different from what Lifetime normally does, and the network is really excited about it — a new way of telling stories, with five short films together.”

Premiering Monday (10/10) on Lifetime, the film also boasts five directors — Aniston, Alicia Keys, Demi Moore, Patty Jenkins and Penelope Spheeris. Tripplehorn’s oncologist character provides the through line, and she got to get a taste of all the women’s directing styles.

Demi Moore was “very detail-oriented, very specific about what she wanted. Her concentration was just so amazing,” Tripplehorn says. With Aniston, “The whole mood on the set was this easy kind of feeling. Her spirit infused the whole set.

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